Moonlighter 2 Moves Will to Tresna and a 3D View
The sequel keeps the loop that carried the first game, dungeon runs into shop sales, but changes the setting, protagonist's standing, and camera perspective, which is what a returning player will judge it on.
Reporting from 1 source: Automaton.
Moonlighter 2: The Endless Vault shifts the series out of Rynoka Village, opening with shopkeeper-adventurer Will thrown into a wasteland by Tresna's owner, Miss Scratch, and made to fill his backpack with relics. The sequel also moves from the previous game's 2D top-down view to a 3D top-down view from diagonally above, with height differences built into the dungeon areas.
Moonlighter 2: The Endless Vault takes Will out of Rynoka Village and drops him in Tresna, where Miss Scratch runs things and hands him back his backpack. His job there is to fill it with relics in the wasteland and bring them home.
The wasteland works as the tutorial, teaching movement, combat, and the relic system. Relics carry rarities and curses that affect the relics placed around them, including one that raises a relic's value at the cost of burning the adjacent relic and one that grants armor so a relic does not burn. Curse types change with the dungeon.
Synthesized by Yomimono from the 1 cited source below, including Japanese-language reporting where cited, then editorially reviewed before publishing.